Peroxidase-like activity of nanocrystalline cobalt selenide and its application for uric acid detection

نویسندگان

  • Quan-Quan Zhuang
  • Zhi-Hang Lin
  • Yan-Cheng Jiang
  • Hao-Hua Deng
  • Shao-Bin He
  • Li-Ting Su
  • Xiao-Qiong Shi
  • Wei Chen
چکیده

Dendrite-like cobalt selenide nanostructures were synthesized from cobalt and selenium powder precursors by a solvothermal method in anhydrous ethylenediamine. The as-prepared nanocrystalline cobalt selenide was found to possess peroxidase-like activity that could catalyze the reaction of peroxidase substrates in the presence of H2O2. A spectrophotometric method for uric acid (UA) determination was developed based on the nanocrystalline cobalt selenide-catalyzed coupling reaction between N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt and 4-aminoantipyrine (4-AAP) in the presence of H2O2. Under optimum conditions, the absorbance was proportional to the concentration of UA over the range of 2.0-40 μM with a detection limit of 0.5 μM. The applicability of the proposed method has been validated by determination of UA in human serum samples with satisfactory results.

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عنوان ژورنال:

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2017